Technology Process of (4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide
There total 4 articles about (4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / H2 / Lindlar catalyst / ethyl acetate
2: 89 percent / PPTS / dimethylformamide
3: 94 percent / NaI, NaHCO3, Na2SO3 / acetone
4: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF
With
chloro-trimethyl-silane; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc;
Lindlar's catalyst;
In
ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja963195c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94 percent / NaI, NaHCO3, Na2SO3 / acetone
2: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF
With
chloro-trimethyl-silane; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc;
In
acetone;
DOI:10.1021/ja963195c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 89 percent / PPTS / dimethylformamide
2: 94 percent / NaI, NaHCO3, Na2SO3 / acetone
3: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF
With
chloro-trimethyl-silane; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc;
In
N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja963195c
