(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Base Information

Chemical Name:(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide
CAS No.:187756-39-4
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

Synonyms:(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

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Chemical Property of (4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

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Technology Process of (4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

There total 4 articles about (4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18927-36-1
6-chloro-1,1-diethoxy-2-hexyne

: 187756-39-4
(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / Lindlar catalyst / ethyl acetate

2: 89 percent / PPTS / dimethylformamide

3: 94 percent / NaI, NaHCO₃, Na₂SO₃ / acetone

4: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF

With chloro-trimethyl-silane; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc; Lindlar's catalyst; In ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja963195c

Reference yield:

: 183274-40-0
(4R,5R)-2-((E)-5-Chloro-pent-1-enyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

: 187756-39-4
(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaI, NaHCO₃, Na₂SO₃ / acetone

2: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF

With chloro-trimethyl-silane; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc; In acetone;
DOI:10.1021/ja963195c

Reference yield:

: 187756-45-2
(E)-6-Chloro-1,1-diethoxy-hex-2-ene

: 187756-39-4
(4R,5R)-2-[(E)-6-(2,4-Dimethoxy-phenyl)-6-oxo-hex-1-enyl]-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / PPTS / dimethylformamide

2: 94 percent / NaI, NaHCO₃, Na₂SO₃ / acetone

3: 1) Zn, TMSCl, 1,2-dibromoethane, 2) CuCN*LiCl / 1) THF

With chloro-trimethyl-silane; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ethylene dibromide; sodium iodide; sodium sulfite; zinc; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja963195c