(S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate

Base Information

• Chemical Name: (S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate
• CAS No.: 1259130-31-8
• Molecular Formula: C₂₃H₂₇NO₅S
• Molecular Weight: 429.537
• Mol file: 1259130-31-8.mol

Synonyms:(S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate

Chemical Property of (S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate

There total 1 articles about (S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene (141332-74-3) + S-benzyl malonic acid half thioester (61668-14-2) → (S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate (1259130-31-8)

Guidance literature:

With lanthanum(III) isopropoxide; C₃₀H₂₆N₂NiO₄; Tetra-P-phenyl-P,P'-hexanediyl-bis-phosphine oxide; In tetrahydrofuran; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/asia.201000540

Reference yield: 83.0%

(S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate (1259130-31-8) → (S)-rolipram (85416-73-5)

Guidance literature:

(S)-S-benzyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanethioate; With chloro-trimethyl-silane; zinc; In ethanol; at 0 - 20 ℃; for 0.333333h;

With water; sodium hydrogencarbonate; In ethanol; at 20 ℃;

DOI:10.1002/asia.201000540

upstream raw materials:

2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

S-benzyl malonic acid half thioester

Downstream raw materials:

(S)-rolipram