3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide

Base Information

• Chemical Name: 3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide
• CAS No.: 1187946-92-4
• Molecular Formula: C₁₁H₁₂FN₃O₃
• Molecular Weight: 253.233

Synonyms:3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide

Chemical Property of 3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide

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Technology Process of 3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide

There total 1 articles about 3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbonitrile (1187946-87-7) → 3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide (1187946-92-4)

Guidance literature:

With hydroxylamine hydrochloride; water; sodium carbonate; In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2009.06.052

Reference yield: 75.0%

3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide (1187946-92-4) + 2,3-dimethoxybenzoic acid (1521-38-6) → 5-(2,3-dimethoxyphenyl)-3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-1,2,4-oxadiazole (1187947-29-0)

Guidance literature:

With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 - 100 ℃;

DOI:10.1016/j.bmcl.2009.06.052

Reference yield: 67.0%

3-(3-fluoro-4-methoxyphenyl)-N'-hydroxy-4,5-dihydroisoxazole-5-carboximidamide (1187946-92-4) + N-Methylisatoic anhydride (10328-92-4) → 2-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-1,2,4-oxadiazol-5-yl)phenyl(methyl)carbamic acid (1187947-24-5)

Guidance literature:

With pyridine; at 100 - 120 ℃;

DOI:10.1016/j.bmcl.2009.06.052

upstream raw materials:

3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbonitrile

Downstream raw materials:

3-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-1,2,4-oxadiazol-5-yl)propionic acid

5-(2,3-dimethoxyphenyl)-3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-1,2,4-oxadiazole

2-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-1,2,4-oxadiazol-5-yl)phenyl(methyl)carbamic acid

3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-5-methyl-1,2,4-oxadiazole

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