3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

Base Information

Chemical Name:3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine
CAS No.:1400691-90-8
Molecular Formula:C₂₀H₂₅N₇O
Molecular Weight:379.465
Hs Code.:

Synonyms:3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

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Chemical Property of 3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

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Technology Process of 3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

There total 5 articles about 3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 95-46-5
2-methylphenyl bromide

: 1400692-23-0
C₁₃H₁₉N₇O

: 1400691-90-8
3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

Guidance literature:: With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-butyl alcohol; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 105170-27-2
2-bromo-5-methoxypyridine

: 1400691-90-8
3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 48 h / 100 °C / Inert atmosphere

2: hydrogenchloride / isopropyl alcohol / 16 h / 20 °C

3: dichloromethane / 1.5 h / 20 °C

4: isopropyl alcohol / 16 h / Reflux

5: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 158399-62-3
1-(5-methoxypyridin-2-yl)piperazine

: 1400691-90-8
3-[4-(5-methoxy-2-pyridinyl)-1-piperazinyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1.5 h / 20 °C

2: isopropyl alcohol / 16 h / Reflux

3: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere

With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; isopropyl alcohol; tert-butyl alcohol;