4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

Base Information

Chemical Name:4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester
CAS No.:936633-35-1
Molecular Formula:C₅₁H₇₄N₅O₁₂P
Molecular Weight:980.149
Hs Code.:

4-{2-<i>tert</i>-butoxycarbonylmethyl-3-[4-(di-<i>tert</i>-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

Synonyms:4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

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Chemical Property of 4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

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Technology Process of 4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

There total 7 articles about 4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 936633-22-6
N-{4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidin-4-yl}-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

: 628-12-6
2-Methoxyethyl chloroformate

: 936633-35-1
4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

Guidance literature:: With diisopropylamine;
DOI:10.1021/jm0614073

Reference yield:

: 4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid monobenzyl ester

: 936633-35-1
4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-hydroxybenzotriazole; DIPCDI; DIPEA / dimethylformamide

2: NHEt₂ / acetonitrile

3: 59 percent / N-hydroxy-9-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 21.25 h / 20 - 40 °C

4: hydrogen / Pd/C / methanol

5: 74 percent / diisopropylamine

With 4-aza-1-hydroxybenzotriazole; 1,3-di-tert-butylcarbodiimide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0614073

Reference yield:

: 936633-15-7
4-amino-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester

: 936633-35-1
4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / N-hydroxy-9-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 21.25 h / 20 - 40 °C

2: hydrogen / Pd/C / methanol

3: 74 percent / diisopropylamine

With 4-aza-1-hydroxybenzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0614073