2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

Base Information

Chemical Name:2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide
CAS No.:1190423-73-4
Molecular Formula:C₃₀H₂₈N₄O₃
Molecular Weight:492.577
Hs Code.:

Synonyms:2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

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Chemical Property of 2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

Chemical Property:

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Technology Process of 2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

There total 9 articles about 2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190423-60-9
4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-[(4-trans-hydroxycyclohexyl)amino]benzamide

: 1190423-73-4
2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; for 2h; Reflux;

Reference yield:

: 130722-95-1
3-(benzyloxy)-5-bromopyridine

: 1190423-73-4
2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

1.2: -20 °C / Inert atmosphere

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Reflux; Inert atmosphere

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / Reflux; Inert atmosphere

4.1: potassium carbonate / dimethyl sulfoxide / 1.33 h / 90 °C / microwave irradiation

5.1: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 1 h / 20 °C

6.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

With n-butyllithium; water; dihydrogen peroxide; ammonium formate; potassium carbonate; caesium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1190423-73-4
2-[(4-trans-hydroxycyclohexyl)amino]-4-[4-(5-hydroxypyridin-3-yl)-9H-carbazol-9-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / Reflux; Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 1.33 h / 90 °C / microwave irradiation

3: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 1 h / 20 °C

4: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

With water; dihydrogen peroxide; ammonium formate; potassium carbonate; caesium carbonate; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide;