N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

Base Information

Chemical Name:N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate
CAS No.:1145835-80-8
Molecular Formula:C₂₁H₁₈FN₅O*H₂O
Molecular Weight:393.421
Hs Code.:

Synonyms:N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

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Technology Process of N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

There total 2 articles about N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 796967-16-3
linifanib

: 1145835-80-8
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

Guidance literature:: linifanib; With acetic acid; ascorbic acid; In ethanol; at 25 - 30 ℃; for 0.5h;

With water; In ethanol; at 20 - 30 ℃; for 1h; Product distribution / selectivity;

Reference yield: 76.0%

: N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea hydrochloride

: 1145835-80-8
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

Guidance literature:: N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea hydrochloride; With disodium hydrogenphosphate; In ethanol; ethyl acetate;

With water; In ethanol; at 25 ℃;