ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate

Base Information

• Chemical Name: ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate
• CAS No.: 595610-33-6
• Molecular Formula: C₁₃H₁₃ClO₄
• Molecular Weight: 268.697
• Mol file: 595610-33-6.mol

Synonyms:ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate

Chemical Property of ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate

There total 1 articles about ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-chlorophenylacetone (14123-60-5) + oxalic acid diethyl ester (95-92-1) → ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate (595610-33-6)

Guidance literature:

3-chlorophenylacetone; With potassium tert-butylate; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h;

oxalic acid diethyl ester; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2021.113325

Reference yield: 69.0%

ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate (595610-33-6) → ethyl 3-(3-chlorobenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:

With hydrazine hydrate; In acetic acid; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2021.113325

Reference yield:

ethyl 5-(3-chlorophenyl)-2,4-dioxopentanoate (595610-33-6) → 3-(3-chlorobenzyl)-N-(2,4-dimethoxyphenyl)-1H-pyrazole-5-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / acetic acid / 12 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 50 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 20 °C

With dmap; lithium hydroxide monohydrate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetic acid;

DOI:10.1016/j.ejmech.2021.113325

upstream raw materials:

3-chlorophenylacetone

oxalic acid diethyl ester