N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide

Base Information

• Chemical Name: N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide
• CAS No.: 1192470-96-4
• Molecular Formula: C₂₉H₂₅ClN₂O₆
• Molecular Weight: 532.98
• Mol file: 1192470-96-4.mol

Synonyms:N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide

Chemical Property of N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide

There total 1 articles about N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-(3-chloropropoxy)-2-nitrobenzoic acid (1192470-92-0) + 4-(4-benzyloxyphenoxy)-phenylamine (155828-47-0) → N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide (1192470-96-4)

Guidance literature:

With dmap; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 17h; Inert atmosphere;

DOI:10.1016/j.bmc.2009.07.063

Reference yield:

N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)-2-nitrobenzamide (1192470-96-4) → 2-amino-N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)benzamide (1192471-01-4)

Guidance literature:

With sodium dithionite; In tetrahydrofuran; ethanol; water; for 2h; Reflux;

DOI:10.1016/j.bmc.2009.07.063

upstream raw materials:

5-(3-chloropropoxy)-2-nitrobenzoic acid

4-(4-benzyloxyphenoxy)-phenylamine

Downstream raw materials:

2-amino-N-[4-(4-benzyloxyphenoxy)phenyl]-5-(3-chloropropoxy)benzamide