N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide

Base Information

• Chemical Name: N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide
• CAS No.: 208511-31-3
• Molecular Formula: C₃₅H₄₁NO₁₂S
• Molecular Weight: 699.776
• Mol file: 208511-31-3.mol

Synonyms:N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide

Chemical Property of N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide

There total 3 articles about N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide (16695-22-0) + diethyl 5-hydroxyisophthalate (39630-68-7) → N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide (208511-31-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 168h; Heating;

DOI:10.1002/(SICI)1521-3765(19980515)4:5<781::AID-CHEM781>3.0.CO;2-3

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide (208511-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / H₂SO₄ / 120 h / Heating

2: 83 percent / K₂CO₃ / acetonitrile / 168 h / Heating

With sulfuric acid; potassium carbonate; In acetonitrile;

DOI:10.1002/(SICI)1521-3765(19980515)4:5<781::AID-CHEM781>3.0.CO;2-3

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide (208511-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

2: 83 percent / K₂CO₃ / acetonitrile / 168 h / Heating

With dmap; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/(SICI)1521-3765(19980515)4:5<781::AID-CHEM781>3.0.CO;2-3

upstream raw materials:

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide

diethyl 5-hydroxyisophthalate

5-Hydroxyisophthalic acid

p-toluenesulfonyl chloride