3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

Base Information

Chemical Name:3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester
CAS No.:209049-30-9
Molecular Formula:C₂₃H₃₈O₄Si
Molecular Weight:406.638
Hs Code.:

Synonyms:3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

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Chemical Property of 3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

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Technology Process of 3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

There total 1 articles about 3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144425-46-7
(±) 4-(tert-butyldimethylsilyloxy)-1-phenylbut-2-yn-1-ol

: 209049-30-9
3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Lindlar catalyst / ethyl acetate / 760 Torr

2: 53 percent / NaH / 18 h / 100 °C

With hydrogen; sodium hydride; Lindlar's catalyst; In ethyl acetate;

Reference yield: 65.0%

: 209049-30-9
3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

: 209049-38-7
3-((Z)-4-Hydroxy-1-phenyl-but-2-enyloxy)-propionic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 209049-30-9
3-[(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-but-2-enyloxy]-propionic acid tert-butyl ester

: (3RS,4SR,5SR)-4-ethenyl-5-phenyltetrahydrofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

2: 85 percent / NaOH / methanol / 2.5 h / Heating

3: 22 percent / DCC, DMAP*HCl / CHCl₃

4: 88 percent / LDA, TMSCl / tetrahydrofuran; hexane / 1.) -100 to -30 deg C, 2.) 1 h

With sodium hydroxide; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; 4-(dimethylamino)pyridine hydrochloride; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; chloroform;