(S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine

Base Information

• Chemical Name: (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine
• CAS No.: 690998-84-6
• Molecular Formula: C₂₅H₃₄N₂O₂
• Molecular Weight: 394.557
• Mol file: 690998-84-6.mol

Synonyms:(S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine

Chemical Property of (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine

There total 1 articles about (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7) + 7-bromoheptyl alcohol (10160-24-4) → (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine (690998-84-6)

Guidance literature:

With triethylamine; In acetonitrile; at 40 - 50 ℃; for 9h;

Reference yield: 98.0%

(S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine (690998-84-6) → (S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-oxohept-1-yl)pyrrolidine (690998-85-7)

Guidance literature:

With sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 - -10 ℃; for 1.16667 - 1.5h;

Reference yield: 13.0%

(S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-hydroxyhept-1-yl)pyrrolidine (690998-84-6) + methanesulfonic acid 7-{[1-(2,6-dimethoxybenzyl)piperidin-4-yl]isopropylamino}heptyl ester (832082-29-8) → 4-{N-[7-(3-(S)-(1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl]-N-(isopropyl)amino}-1-(2,6-dimethoxybenzyl)piperidine

Guidance literature:

With triethylamine; In acetonitrile; at 60 ℃; for 18h;

upstream raw materials:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

7-bromoheptyl alcohol

Downstream raw materials:

(S)-3-(1-carbamoyl-1,1-diphenylmethyl)-1-(7-oxohept-1-yl)pyrrolidine