3-benzoxypropyl trimethylsilyl ketone

Base Information

• Chemical Name: 3-benzoxypropyl trimethylsilyl ketone
• CAS No.: 107399-13-3
• Molecular Formula: C₁₃H₂₀O₂Si
• Molecular Weight: 236.386
• Mol file: 107399-13-3.mol

Synonyms:3-benzoxypropyl trimethylsilyl ketone

Chemical Property of 3-benzoxypropyl trimethylsilyl ketone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-benzoxypropyl trimethylsilyl ketone

There total 2 articles about 3-benzoxypropyl trimethylsilyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(3-benzyloxypropyl)-2-(trimethylsilyl)-1,3-dithiane → 3-benzoxypropyl trimethylsilyl ketone (107399-13-3)

Guidance literature:

With N-chloro-succinimide; water; silver nitrate; In tetrahydrofuran; acetonitrile; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/chem.201904635

Reference yield: 66.0%

(1-Diazo-4-phenoxy-butyl)-trimethyl-silane → 3-benzoxypropyl trimethylsilyl ketone (107399-13-3)

Guidance literature:

With phosphate buffer; 3-chloro-benzenecarboperoxoic acid; In benzene; pH 7.6; 6-10 deg C, 5 min then r.t., 30 min;

DOI:10.1016/S0040-4039(00)84433-0

Reference yield:

3-benzoxypropyl trimethylsilyl ketone (107399-13-3) + cinnamyl tert-butyl carbonate (124517-47-1) → 2-(2-phenoxyethyl)-3-phenyl-1-(trimethylsilyl)pent-4-en-1-one (1254704-23-8) + 2-(2-phenoxyethyl)-3-phenyl-1-(trimethylsilyl)pent-4-en-1-one + 2-(2-phenoxyethyl)-3-phenyl-1-(trimethylsilyl)pent-4-en-1-one

Guidance literature:

3-benzoxypropyl trimethylsilyl ketone; With lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; at 0 ℃; for 0.5h; Inert atmosphere;

With bis(η3-allyl-μ-chloropalladium(II)); (Rphos,R)-SIOC-Phox; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 ℃; for 0.5h; Inert atmosphere;

cinnamyl tert-butyl carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja106703y

Downstream raw materials:

2-(2-phenoxyethyl)-3-phenyl-1-(trimethylsilyl)pent-4-en-1-one