7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride

Base Information

• Chemical Name: 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride
• CAS No.: 1334784-97-2
• Molecular Formula: C₁₆H₂₂N₂O₂*ClH
• Molecular Weight: 310.824
• Mol file: 1334784-97-2.mol

Synonyms:7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride

Chemical Property of 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride

There total 1 articles about 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate (1334784-96-1) → 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride (1334784-97-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield: 85.0%

5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-one (1334784-74-5) + 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride (1334784-97-2) → 7-[(4-methoxyphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane (1334782-53-4)

Guidance literature:

5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-one; 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane hydrochloride; With titanium(IV)isopropoxide; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 16h;

upstream raw materials:

tert-butyl 7-[(4-methoxyphenyl)acetyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate

Downstream raw materials:

7-[(4-methoxyphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane