{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

Base Information

Chemical Name:{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid
CAS No.:1404529-43-6
Molecular Formula:C₂₆H₂₆N₄O₄
Molecular Weight:458.517
Hs Code.:

Synonyms:{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

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Chemical Property of {3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

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Technology Process of {3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

There total 22 articles about {3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1404532-64-4
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methyl-indol-1-yl}acetic acid methyl ester

: 1404529-43-6
{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1021/jm500588w

Reference yield:

: 1-acetyl-5-methyl-1H-indole-3-carboxylic acid

: 1404529-43-6
{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C

2: potassium carbonate / methanol / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: sodium hydroxide; water / methanol / 20 °C

With dmap; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm500588w

Reference yield:

: 858515-93-2
2,2,2-trifluoro-1-(5-methyl-1H-indol-3-yl)-ethanone

: 1404529-43-6
{3-[4-(4-butyryl-5-methylpyrazol-1-yl)phenylcarbamoyl]-5-methylindol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; water / Reflux

2: dmap; triethylamine / dichloromethane / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C

4: potassium carbonate / methanol / 4 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6: sodium hydroxide; water / methanol / 20 °C

With dmap; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm500588w