N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne

Base Information

• Chemical Name: N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne
• CAS No.: 443306-08-9
• Molecular Formula: C₂₃H₃₃F₂NO₂SSi
• Molecular Weight: 453.669
• Mol file: 443306-08-9.mol

Synonyms:N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne

Chemical Property of N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne

There total 1 articles about N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methyl-N-prop-2-ynylbenzenesulfonamide (55022-46-3) + 1,1-difluoro-3-(triisopropylsilyl)-1,2-butadiene-4-ol (306966-64-3) → N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne (443306-08-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0022-1139(02)00158-6

Reference yield: 90.0%

N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne (443306-08-9) → N-tosyl-3,3-difluoro-5-triisopropylsilyl-7-aza-bicyclo[4.2.0]-octa-1,4-diene

Guidance literature:

With hexacarbonyl molybdenum; In dimethyl sulfoxide; toluene; at 100 ℃;

DOI:10.1021/ja0263893

Reference yield: 86.0%

N-tosyl-1,1-difluoro-3-triisopropylsilyl-5-aza-octa-1,2-dien-7-yne (443306-08-9) → N-tosyl-1,1-difluoro-5-aza-octa-2,7-diyne

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; for 6h;

DOI:10.1021/ja0263893

upstream raw materials:

4-methyl-N-prop-2-ynylbenzenesulfonamide

1,1-difluoro-3-(triisopropylsilyl)-1,2-butadiene-4-ol