2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine
CAS No.:1420468-88-7
Molecular Formula:C₂₁H₂₂F₃N₃O
Molecular Weight:389.42
Hs Code.:

Synonyms:2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

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Chemical Property of 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

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Technology Process of 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

There total 8 articles about 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1420468-87-6
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

: 1420468-88-7
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With dmap; palladium on activated charcoal; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield: 21.0%

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: hexaformylmolybdenum

: 1420468-87-6
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

: 1420468-88-7
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol;

Reference yield:

: 1420468-30-9
2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-3-oxobutanenitrile

: 1420468-88-7
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

2: acetic acid / 0.67 h / 140 °C / Microwave irradiation

3: N,N-diethylaniline; trichlorophosphate / 2 h / 0 - 80 °C / Inert atmosphere

4: dmap; molybdenum hexacarbonyl; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon / ethanol; 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

With dmap; palladium 10% on activated carbon; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; molybdenum hexacarbonyl; trichlorophosphate; In 1,4-dioxane; ethanol;
DOI:10.1021/ml300330m