4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide

Base Information

• Chemical Name: 4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide
• CAS No.: 1415218-79-9
• Molecular Formula: C₂₂H₁₃F₄NO
• Molecular Weight: 383.345
• Mol file: 1415218-79-9.mol

Synonyms:4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide

Chemical Property of 4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide

There total 1 articles about 4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C14H8F4INO + phenylacetylene (536-74-3) → 4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide (1415218-79-9)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; Inert atmosphere;

DOI:10.1002/adsc.201200018

Reference yield: 88.0%

4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide (1415218-79-9) → (Z)-4-benzylidene-2-(4-fluorophenyl)-6-(trifluoromethyl)-4H-benzo[d][1,3]oxazine

Guidance literature:

With iodine; In toluene; for 72h; stereoselective reaction; Inert atmosphere; Reflux;

DOI:10.1002/adsc.201200018

Reference yield:

4-fluoro-N-[2-(phenylethynyl)-4-(trifluoromethyl)phenyl]benzamide (1415218-79-9) → 4-benzyl-2-(4-fluorophenyl)-6-(trifluoromethyl)quinazoline 3-oxide

Guidance literature:

Multi-step reaction with 2 steps

1: iodine / toluene / 72 h / Inert atmosphere; Reflux

2: potassium carbonate; hydroxylamine hydrochloride / dichloromethane; methanol / 10 h / 20 °C

With hydroxylamine hydrochloride; iodine; potassium carbonate; In methanol; dichloromethane; toluene;

DOI:10.1002/adsc.201200018

upstream raw materials:

phenylacetylene