allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

Base Information

Chemical Name:allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside
CAS No.:288403-15-6
Molecular Formula:C₅₈H₉₅Cl₃NO₁₂PSi
Molecular Weight:1163.81
Hs Code.:

allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

Synonyms:allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

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Chemical Property of allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

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Technology Process of allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

There total 12 articles about allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 288403-14-5
allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(hydroxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

: 112-64-1
tetradecanoyl chloride

: 288403-15-6
allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0008-6215(01)00134-3

Reference yield: 95.0%

: 288403-15-6
allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

Guidance literature:

Reference yield:

: 288402-98-2
(R)-1-methanesulfonyloxy-3-(4-methoxybenzyloxy)tetradecane

: 288403-15-6
allyl 6-O-(tert-butyldimethylsilyl)-2-deoxy-4-O-(diphenylphosphono)-3-O-[(R)-3-(tetradecanoyloxy)tetradecyl]-2-[(2,2,2-trichloroethoxycarbonyl)amino]-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH (in oil)77 / dimethylformamide / 0.25 h / 0 °C

1.2: 84 percent / dimethylformamide / 18 h / 20 °C

2.1: 99 percent / aq. NaOH / ethanol

3.1: 94 percent / 0.5 h / 20 °C

4.1: 83 percent / 80 percent AcOH / H₂O / 1 h / 60 °C

5.1: 96 percent / DMAP / CH₂Cl₂ / 3 h / 20 °C

6.1: 98 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

7.1: 91 percent / DDQ / CH₂Cl₂ / 1 h / 20 °C

8.1: 95 percent / Et₃N; DMAP / tetrahydrofuran / 24 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(01)00134-3