N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Base Information

Chemical Name:N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide
CAS No.:200400-56-2
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:

Synonyms:N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Suppliers and Price of N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

There total 15 articles about N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7170-38-9
3-phenoxypropanoic acid

: 200400-56-2
N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: H₂, AcOH / 5 percent Rh/C / 4 h / 50 °C

2: LAH / diethyl ether / 0 °C

3: Et₃N / dimethylformamide / 1 h / 0 °C

4: NaN₃ / dimethylformamide; H₂O / 60 - 70 °C

5: H₂O, Ph₃P / tetrahydrofuran / Ambient temperature

6: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

7: TFA / CH₂Cl₂ / 0 - 20 °C

8: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

9: PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

10: NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; lithium aluminium tetrahydride; sodium azide; 4 A molecular sieve; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; Rh on carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n

Reference yield:

: 200400-48-2
(S)-2-[4-(Pyridine-3-carbonyl)-phenyl]-4,5-dihydro-oxazole-4-carboxylic acid (3-cyclohexyloxy-propyl)-amide

: 200400-56-2
N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: With nickel(IV) oxide; 4 A molecular sieve; In 1,4-dioxane; benzene; for 4h; Yield given; Heating;
DOI:10.1021/jm980173n

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 200400-56-2
N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) Et₂O, hexane, -78 deg C, 25 min, 2.) Et₂O, hexane, a) -78 deg C, 2 h, b) RT, 2 h

2: 81 percent / MnO₂ / tetrahydrofuran / 17 h / 70 °C

3: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

4: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

5: PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

6: NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; manganese(IV) oxide; nickel(IV) oxide; sodium hydroxide; n-butyllithium; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n