4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE

Base Information

• Chemical Name: 4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
• CAS No.: 169057-08-3
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.252
• Hs Code.: 2933998090
• Mol file: 169057-08-3.mol

Synonyms:C₁₃H₁₃NO

Chemical Property of 4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

4-(1-Methyl-1H-indol-3-yl)but-3-en-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE

There total 2 articles about 4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-methyl-3-formylindole (19012-03-4) + 1-triphenylphosphoranylidene-2-propanone (1439-36-7) → C13H13NO (169057-08-3)

Guidance literature:

In toluene; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.10.079

Reference yield:

C19H27NOSi → C13H13NO (169057-08-3)

Guidance literature:

With ethyl 2-(benzylimino)acetate; zinc(II) chloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200800284

Reference yield: 86.0%

C13H13NO (169057-08-3) + trans-2-phenylvinylboronic acid (6783-05-7) → C21H21NO

Guidance literature:

With 3,3'-dipentafluorophenyl-2,2'-binaphthol; magnesium 2-methylpropan-2-olate; In 1,2-dichloro-ethane; at 70 ℃; enantioselective reaction; Molecular sieve;

DOI:10.1002/chir.22134

upstream raw materials:

N-methyl-3-formylindole

1-triphenylphosphoranylidene-2-propanone