{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

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Chemical Name:{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane
CAS No.:646520-53-8
Molecular Formula:C₂₄H₄₂O₇Si
Molecular Weight:470.679
Hs Code.:

Synonyms:{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

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Chemical Property of {2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

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Technology Process of {2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

There total 7 articles about {2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 824-94-2
p-methoxybenzyl chloride

: 646520-52-7
(2S,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(2-trimethylsilanyl-ethoxymethoxy)-butan-1-ol

: 646520-53-8
{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

Guidance literature:: (2S,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(2-trimethylsilanyl-ethoxymethoxy)-butan-1-ol; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 1.5h;

p-methoxybenzyl chloride; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1021/ja0304953

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 646520-53-8
{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / diisopropylethylamine; tetra-n-butylammonium chloride / CH₂Cl₂ / 7 h / 40 °C

2.1: 81 percent / lithium triethylborohydride / tetrahydrofuran / 3 h / 0 °C

3.1: NaH / dimethylformamide / 1.5 h / 25 °C

3.2: 83 percent / tetra-n-butylammnonium iodide / dimethylformamide / 24 h / 25 °C

With tetrabutyl-ammonium chloride; sodium hydride; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0304953

Reference yield:

: (3S,5S)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-dihydro-furan-2-one

: 646520-53-8
{2-[(1S,3S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-1-(4-methoxy-benzyloxymethyl)-propoxymethoxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: CH₂Cl₂ / 7 h / 25 °C

2.1: 15 h / 65 °C

3.1: benzyltriethylammonium chloride; aq. NaOH / CH₂Cl₂ / 0.5 h / 25 °C

3.2: CH₂Cl₂ / 12 h / 25 °C

4.1: 28.2 g / pyridinium p-toluenesulfonate / methanol / 3 h / 25 °C

5.1: 99 percent / diisopropylethylamine; tetra-n-butylammonium chloride / CH₂Cl₂ / 7 h / 40 °C

6.1: 81 percent / lithium triethylborohydride / tetrahydrofuran / 3 h / 0 °C

7.1: NaH / dimethylformamide / 1.5 h / 25 °C

7.2: 83 percent / tetra-n-butylammnonium iodide / dimethylformamide / 24 h / 25 °C

With sodium hydroxide; tetrabutyl-ammonium chloride; N-benzyl-N,N,N-triethylammonium chloride; pyridinium p-toluenesulfonate; sodium hydride; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0304953