2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate

Base Information

Chemical Name:2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate
CAS No.:1038992-46-9
Molecular Formula:C₂₃H₂₂F₄N₄O₅S
Molecular Weight:542.511
Hs Code.:

Synonyms:2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate

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Chemical Property of 2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate

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Technology Process of 2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate

There total 1 articles about 2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 500108-01-0
(4-fluorophenyl)methanesulfonamide

: 1038992-87-8
1-{3-cyano-6-methyl-5-[(2,2,2-trifluoroethoxy)carbonyl]pyridin-2-yl}piperidine-4-carboxylic acid

: 1038992-46-9
2,2,2-trifluoroethyl 5-cyano-6-(4-{[(4-fluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methylnicotinate

Guidance literature:: 1-{3-cyano-6-methyl-5-[(2,2,2-trifluoroethoxy)carbonyl]pyridin-2-yl}piperidine-4-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

(4-fluorophenyl)methanesulfonamide; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 2h;