2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

Base Information

• Chemical Name: 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid
• CAS No.: 1453861-72-7
• Molecular Formula: C₂₉H₃₂O₇S
• Molecular Weight: 524.635
• Mol file: 1453861-72-7.mol

Synonyms:2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

Chemical Property of 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

There total 10 articles about 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate (1453861-71-6) → 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid (1453861-72-7)

Guidance literature:

With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

3'-(hydroxymethyl)-2-methyl-[1,1'-biphenyl]-4-ol (1453862-23-1) → 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid (1453861-72-7)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: phosphorus tribromide / dichloromethane / 1 h / 0 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4: lithium hydroxide monohydrate; methanol / tetrahydrofuran / 6 h / 20 °C

With methanol; lithium hydroxide monohydrate; phosphorus tribromide; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methanol (1429789-80-9) → 2-(3-(4-((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid (1453861-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus tribromide / dichloromethane / 1 h / 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: lithium hydroxide monohydrate; methanol / tetrahydrofuran / 6 h / 20 °C

With methanol; lithium hydroxide monohydrate; phosphorus tribromide; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4’-hydroxy-2’-methyl-3-biphenylcarbaldehyde

4-bromo-3-methylphenol

3-Formylphenylboronic acid

3'-(hydroxymethyl)-2-methyl-[1,1'-biphenyl]-4-ol