{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Base Information

Chemical Name:{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid
CAS No.:1451093-44-9
Molecular Formula:C₂₅H₁₇F₃O₄S
Molecular Weight:470.469
Hs Code.:

Synonyms:{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

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Chemical Property of {4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Chemical Property:

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Technology Process of {4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

There total 14 articles about {4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451093-46-1
{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

: 1451093-44-9
{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: {4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=Ca. 2;

Reference yield:

: 1451093-04-1
1-(4-bromo-phenylsulfanyl)-2,6-difluoro-benzene

: 1451093-44-9
{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 20 °C

3.2: pH Ca_. 2

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1432911-13-1
6-fluoro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid

: 1451093-44-9
{4-[4-(2,6-difluoro-benzenesulfonyl)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid / 0 °C / Reflux

2.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

5.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol

7.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

11.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 20 °C

11.2: pH Ca_. 2

With pyridine; tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium acetate; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;