C₅₈H₅₄N₆O₈S₄Si

Base Information

• Chemical Name: C₅₈H₅₄N₆O₈S₄Si
• CAS No.: 1025891-61-5
• Molecular Formula: C₅₈H₅₄N₆O₈S₄Si
• Molecular Weight: 1119.45
• Mol file: 1025891-61-5.mol

Synonyms:C₅₈H₅₄N₆O₈S₄Si

Chemical Property of C₅₈H₅₄N₆O₈S₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₈H₅₄N₆O₈S₄Si

There total 13 articles about C₅₈H₅₄N₆O₈S₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

H-L-Cys-OPac + 2-(2-{2'-[1-tert-butoxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-[2,4']bithiazolyl-4-yl}-6-formyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester (1025910-47-7) → C58H54N6O8S4Si (1025891-61-5)

Guidance literature:

H-L-Cys-OPac; 2-(2-{2'-[1-tert-butoxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-[2,4']bithiazolyl-4-yl}-6-formyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester; With triethylamine; In toluene; at 20 ℃; for 0.166667h;

With manganese(IV) oxide; In toluene; at 20 ℃;

Reference yield:

(S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester (95715-86-9,108149-60-6) → C58H54N6O8S4Si (1025891-61-5)

Guidance literature:

Multi-step reaction with 14 steps

1.1: DIBAL-H / toluene / 0.75 h / -78 °C

2.1: diethyl ether / 1 h / 0 °C

3.1: 100 percent / imidazole / CHCl₃ / 0 - 20 °C

4.1: trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

5.1: 92 percent / acetone / 2 h / 0 °C / Jones reagent

6.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

6.2: 77 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

7.1: 100 percent / 1,2-dimethoxy-ethane / 20 °C / Lawesson's reagent

8.1: KHCO₃ / 1,2-dimethoxy-ethane / 1 h / 0 °C

8.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / 0 °C

8.3: 68 percent / aq. NH₃ / ethyl acetate / 0.25 h / 0 °C

9.1: 100 percent / LiOH / methanol / 0 - 20 °C

10.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

10.2: 94 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

11.1: 92 percent / dioxane / 3 h / 70 °C / Lawesson's reagent

12.1: KHCO₃ / 1,2-dimethoxy-ethane / 0 - 20 °C

12.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / 0 °C

12.3: 66 percent / aq. NH₃ / 0.25 h / 0 °C

13.1: aq. HCl / tetrahydrofuran / 20 °C

14.1: Et₃N / toluene / 0.17 h / 20 °C

14.2: 31 percent / MnO₂ / toluene / 20 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; chloroformic acid ethyl ester; diisobutylaluminium hydride; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; chloroform; acetone; toluene; 1.1: Reduction / 2.1: Grignard reaction / 3.1: Substitution / 4.1: Substitution / 5.1: Oxidation / 6.1: Acylation / 6.2: Substitution / 7.1: Substitution / 8.1: Alkylation / 8.2: Cyclization / 8.3: thiazolation / 9.1: Hydrolysis / 10.1: Acylation / 10.2: amidation / 11.1: Substitution / 12.1: Alkylation / 12.2: Cyclization / 12.3: thiazolation / 13.1: Hydrolysis / 14.1: Condensation / 14.2: Oxidation;

Reference yield:

(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (102308-32-7) → C58H54N6O8S4Si (1025891-61-5)

Guidance literature:

Multi-step reaction with 13 steps

1.1: diethyl ether / 1 h / 0 °C

2.1: 100 percent / imidazole / CHCl₃ / 0 - 20 °C

3.1: trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

4.1: 92 percent / acetone / 2 h / 0 °C / Jones reagent

5.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

5.2: 77 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

6.1: 100 percent / 1,2-dimethoxy-ethane / 20 °C / Lawesson's reagent

7.1: KHCO₃ / 1,2-dimethoxy-ethane / 1 h / 0 °C

7.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / 0 °C

7.3: 68 percent / aq. NH₃ / ethyl acetate / 0.25 h / 0 °C

8.1: 100 percent / LiOH / methanol / 0 - 20 °C

9.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

9.2: 94 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

10.1: 92 percent / dioxane / 3 h / 70 °C / Lawesson's reagent

11.1: KHCO₃ / 1,2-dimethoxy-ethane / 0 - 20 °C

11.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / 0 °C

11.3: 66 percent / aq. NH₃ / 0.25 h / 0 °C

12.1: aq. HCl / tetrahydrofuran / 20 °C

13.1: Et₃N / toluene / 0.17 h / 20 °C

13.2: 31 percent / MnO₂ / toluene / 20 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; chloroformic acid ethyl ester; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; chloroform; acetone; toluene; 1.1: Grignard reaction / 2.1: Substitution / 3.1: Substitution / 4.1: Oxidation / 5.1: Acylation / 5.2: Substitution / 6.1: Substitution / 7.1: Alkylation / 7.2: Cyclization / 7.3: thiazolation / 8.1: Hydrolysis / 9.1: Acylation / 9.2: amidation / 10.1: Substitution / 11.1: Alkylation / 11.2: Cyclization / 11.3: thiazolation / 12.1: Hydrolysis / 13.1: Condensation / 13.2: Oxidation;

upstream raw materials:

2-(2-{2'-[1-tert-butoxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-[2,4']bithiazolyl-4-yl}-6-formyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

(S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester

(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(S)-tert-butyl 4-((S)-hydroxy(phenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Downstream raw materials:

C₅₂H₅₁N₇O₈S₄Si