3-(5-ethylpiperidin-2-yl)propan-1-ol

Base Information

• Chemical Name: 3-(5-ethylpiperidin-2-yl)propan-1-ol
• CAS No.: 40235-87-8
• Molecular Formula: C₁₀H₂₁NO
• Molecular Weight: 171.283
• Mol file: 40235-87-8.mol

Synonyms:3-(5-Ethyl-2-piperidyl)-1-propanol;NSC 346488

Chemical Property of 3-(5-ethylpiperidin-2-yl)propan-1-ol

Chemical Property:

• Vapor Pressure: 0.0014mmHg at 25°C
• Boiling Point: 263.9°C at 760 mmHg
• Flash Point: 79.2°C
• Density: 0.893g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(5-ethylpiperidin-2-yl)propan-1-ol

There total 4 articles about 3-(5-ethylpiperidin-2-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(5-ethylpyrid-2-yl)propan-1-ol (61744-44-3) → 3-(5-ethylpiperidin-2-yl)propan-1-ol (40235-87-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; under 3102.9 Torr;

DOI:10.1002/mrc.1260250416

Reference yield:

5-ethyl-2-methyl-pyridine (104-90-5) → 3-(5-ethylpiperidin-2-yl)propan-1-ol (40235-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / 1.) PhLi / diethyl ether / 1.) 0.9 h

2: 95 percent / hydrogen / PtO₂ / acetic acid / 3102.9 Torr

With hydrogen; phenyllithium; platinum(IV) oxide; In diethyl ether; acetic acid;

DOI:10.1002/mrc.1260250416

Reference yield:

5-ethyl-2-methyl-pyridine (104-90-5) → 3-(5-ethylpiperidin-2-yl)propan-1-ol (40235-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: phenyl lithium; diethyl ether / und Behandeln des Reaktionsgemisches mit Aethylenoxid in Aether

2: platinum; acetic acid / Hydrogenation

With diethyl ether; acetic acid; phenyllithium; platinum;

DOI:10.1016/S0304-4181(00)00018-X

upstream raw materials:

3-(5-ethylpyrid-2-yl)propan-1-ol

5-ethyl-2-methyl-pyridine

Downstream raw materials:

trans-(H-5a,H8)-8-Ethylperhydropyrido<1,2-c><1,3>oxazepine

cis-(H-5a,H8)-8-Ethylperhydropyrido<1,2-c><1,3>oxazepine

Refernces

• 1、 Banting, Lee,Crabb, Trevor A.,Trethewey, Andrew N.. "Compounds with Bridgehead Nitrogen 51 The NMR Spectra and Stereochemistry of the 6-Ethylindolizidines". . p. 352 - 355. Retrieved 1987.