4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

Base Information

Chemical Name:4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid
CAS No.:913622-87-4
Molecular Formula:C₂₄H₂₈ClNO₁₃
Molecular Weight:573.938
Hs Code.:

Synonyms:4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

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Chemical Property of 4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

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Technology Process of 4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

There total 9 articles about 4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-4,6-dihydroxy-2-(4-oxo-butyl)-benzoic acid 2-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-ethyl ester

: 913622-87-4
4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;
DOI:10.1021/jo061054f

Reference yield:

: 884646-90-6
2-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)ethanol

: 913622-87-4
4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: NH₄NO₃; (CF₃CO)2O / tetrahydrofuran / 0.25 h / 20 °C

1.2: 61 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

2.1: 90 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

3.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

4.1: 291 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With ammonium nitrate; 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol; 2.1: Mitsunobu esterification;
DOI:10.1021/jo061054f

Reference yield:

: 913622-67-0
3-chloro-4,6-dihydroxy-2-(pent-4-enyl)benzoic acid

: 913622-87-4
4-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

2: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

3: 291 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol; 1: Mitsunobu esterification;
DOI:10.1021/jo061054f