(4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester

Base Information

• Chemical Name: (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester
• CAS No.: 870195-29-2
• Molecular Formula: C₂₈H₂₄Cl₂N₂O₆
• Molecular Weight: 555.414
• Mol file: 870195-29-2.mol

Synonyms:(4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester

Chemical Property of (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester

There total 13 articles about (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide (870194-71-1) + C11H12ClNO4 → (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester (870195-29-2)

Guidance literature:

N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide; With potassium hexamethylsilazane; In diethyl ether; at 20 ℃; for 1h;

C₁₁H₁₂ClNO₄; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2006.08.052

Reference yield:

(4-formyl-2-methyl-phenoxy)-acetic acid methyl ester (476156-34-0) → (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester (870195-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂NOH*HCl; aq. Na₂CO₃ / 2 h / 20 °C

2.1: NCS; HCl(gas) / dimethylformamide / 0.5 h / 20 °C

3.1: potassium bis(trimethylsilyl)amide / diethyl ether / 1 h / 20 °C

3.2: acetonitrile / 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.08.052

Reference yield:

(2-methyl-4-trifluoromethanesulfonyloxy-phenoxy)-acetic acid methyl ester → (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester (870195-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Pd(PPh₃)4 / dimethylformamide / 30 h / 80 °C

2.1: formic acid / Raney-nickel / 10 h / 110 °C

3.1: H₂NOH*HCl; aq. Na₂CO₃ / 2 h / 20 °C

4.1: NCS; HCl(gas) / dimethylformamide / 0.5 h / 20 °C

5.1: potassium bis(trimethylsilyl)amide / diethyl ether / 1 h / 20 °C

5.2: acetonitrile / 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; nickel; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.08.052

upstream raw materials:

N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide

(4-formyl-2-methyl-phenoxy)-acetic acid methyl ester

[4-(hydroxyimino-methyl)-2-methyl-phenoxy]-acetic acid methyl ester

2-(2,4-dichlorophenoxy)ethylamine