biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide

Base Information

• Chemical Name: biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide
• CAS No.: 394248-82-9
• Molecular Formula: C₂₇H₃₂N₂O₃
• Molecular Weight: 432.563

Synonyms:biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide

Chemical Property of biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide

Chemical Property:

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Technology Process of biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide

There total 4 articles about biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

biphenyl-4-carboxylic acid [3-acetyl-4-(2-diethylamino-ethoxy)-phenyl]-amide (394248-94-3) + dichloromethane-aq. ammonia-methanol → biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide (394248-82-9)

Guidance literature:

In tetrahydrofuran; ethanol;

Reference yield:

biphenyl-4-carboxylic acid [3-acetyl-4-(2-diethylamino-ethoxy)-phenyl]-amide (394248-94-3) → biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide (394248-82-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2006.06.056

Reference yield:

1-[5-amino-2-(2-diethylamino-ethoxy)-phenyl]-ethanone → biphenyl-4-carboxylic Acid [4-(2-diethylamino-ethoxy)-3-(1-hydroxy-ethyl)-phenyl]-amide (394248-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 14 h / 20 °C

2: NaBH₄ / ethanol / 5 h / 20 °C

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.06.056

upstream raw materials:

biphenyl-4-carboxylic acid [3-acetyl-4-(2-diethylamino-ethoxy)-phenyl]-amide

4-biphenyl-carboxylic acid chloride

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