4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride

Base Information

• Chemical Name: 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride
• CAS No.: 157396-14-0
• Molecular Formula: C₂₀H₁₇Cl₂NO₃S₂
• Molecular Weight: 454.398
• Mol file: 157396-14-0.mol

Synonyms:4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride

Chemical Property of 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride

There total 4 articles about 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(1-Benzenesulfonyl-1H-pyrrol-2-yl)-4-(4-chloro-phenylsulfanyl)-butyric acid → 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride (157396-14-0)

Guidance literature:

With pyridine; oxalyl dichloride; In benzene; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.42.271

Reference yield:

N-phenylsulfonylpyrrole (16851-82-4) → 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride (157396-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

2: 100 percent / aq. LiOH / tetrahydrofuran / 48 h / Ambient temperature

3: 100 percent / (COCl)2, pyridine / benzene / 0.5 h / Ambient temperature

With pyridine; lithium hydroxide; oxalyl dichloride; titanium tetrachloride; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1248/cpb.42.271

Reference yield:

ethyl 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoate (157396-13-9) → 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride (157396-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq. LiOH / tetrahydrofuran / 48 h / Ambient temperature

2: 100 percent / (COCl)2, pyridine / benzene / 0.5 h / Ambient temperature

With pyridine; lithium hydroxide; oxalyl dichloride; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.42.271

upstream raw materials:

N-phenylsulfonylpyrrole

ethyl 4-chloro-4-(4-chlorophenylthio)butanoate

ethyl 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoate

Downstream raw materials:

7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one

1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-trimethylsilanyloxy-4,5,6,7-tetrahydro-1H-indole-4-carbonitrile

1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-methyl-4,5,6,7-tetrahydro-1H-indol-4-ol

4-methyl-1-phenylsulfonyl-1H-indole