N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

Base Information

Chemical Name:N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine
CAS No.:1449782-29-9
Molecular Formula:C₂₅H₃₂N₁₀O
Molecular Weight:488.595
Hs Code.:

Synonyms:N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

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Chemical Property of N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

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Technology Process of N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

There total 4 articles about N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1449782-21-1
tert-butyl (4-cyclohexylbenzyl){6-morpholino-9-[2-(1-trityl-1H-tetrazol-5-yl)ethyl]-9H-purin-2-yl}carbamate

: 1449782-29-9
N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1449782-29-9
N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 16 h / 50 °C

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 - 40 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 55 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Mitsunobu Displacement / 2.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 1449782-16-4
tert-butyl {6-chloro-9-[2-(1-trityl-1H-tetrazol-5-yl)ethyl]-9H-purin-2-yl}carbamate

: 1449782-29-9
N-(4-cyclohexylbenzyl)-6-morpholino-9-[2-(1H-tetrazol-5-yl)ethyl]-9H-purine-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 - 40 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 55 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.04.080