1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

Base Information

Chemical Name:1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine
CAS No.:644961-33-1
Molecular Formula:C₅₃H₅₄N₂O₁₃Si
Molecular Weight:955.103
Hs Code.:

Synonyms:1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

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Chemical Property of 1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

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Technology Process of 1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

There total 1 articles about 1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: 1,2,3-tri-O-benzoyl-5-O-(phenoxyacetyl)-D-ribofuranose

: 644961-33-1
1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 1.5h;
DOI:10.1081/NCN-120022028

Reference yield: 75.0%

: 644961-33-1
1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

: 644961-34-2
1-[3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1081/NCN-120022028

Reference yield:

: 644961-33-1
1-[5-O-tert-butyldiphenylsilyl-3-O-(2,3-di-O-benzoyl-5-O-phenoxyacetyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

: 644961-36-4
1-[5-O-(4'-monomethoxytrityl)-3-O-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl]thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.33 h / 20 °C

2: pyridine / 16 h / 20 °C

3: 650 mg / NaHCO₃ / methanol / 0.67 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; In tetrahydrofuran; methanol;
DOI:10.1081/NCN-120022028