ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

Base Information

Chemical Name:ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate
CAS No.:219922-49-3
Molecular Formula:C₂₄H₂₉ClN₂O₃
Molecular Weight:428.959
Hs Code.:

Synonyms:ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

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Chemical Property of ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

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Technology Process of ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

There total 6 articles about ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6232-12-8
p-(Aminometyl)benzoic acid ethyl ester hydrochloride

: 758670-25-6
2-(5-chloro-2-piperidino-phenyl)-propanoic acid

: 219922-49-3
ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

Guidance literature:: With tetrachloromethane; triethylamine; triphenylphosphine; In acetonitrile; for 15h; Ambient temperature;
DOI:10.1021/jm9810349

Reference yield:

: 110-89-4
piperidine

: 219922-49-3
ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / 72 h / Heating

2: 56 percent / H₂ / 10 percent Pd/C / dimethylformamide / 2 h / 750.06 Torr / Ambient temperature

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) from 0 deg C to 5 deg C, 2.) from 0 deg C to 50 deg C

4: 70 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With copper(I) chloride; hydrogenchloride; tetrachloromethane; hydrogen; triethylamine; triphenylphosphine; sodium nitrite; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm9810349

Reference yield:

: 2184-85-2
2-(2-chloro-phenyl)-propanoic acid

: 219922-49-3
ethyl 4-<2-<<2-<5-chloro-2-(1-piperidinyl)phenyl>propanoyl>amino>methyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / HNO₃, H₂SO₄ / -25 - -15 °C

2: 94 percent / 72 h / Heating

3: 56 percent / H₂ / 10 percent Pd/C / dimethylformamide / 2 h / 750.06 Torr / Ambient temperature

4: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) from 0 deg C to 5 deg C, 2.) from 0 deg C to 50 deg C

5: 70 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With copper(I) chloride; hydrogenchloride; tetrachloromethane; sulfuric acid; hydrogen; nitric acid; triethylamine; triphenylphosphine; sodium nitrite; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm9810349