2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Base Information

Chemical Name:2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester
CAS No.:126822-63-7
Molecular Formula:C₃₃H₃₇BrO₆Si
Molecular Weight:637.643
Hs Code.:

2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Synonyms:2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Suppliers and Price of 2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

There total 13 articles about 2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5-((R)-1-{(R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-2-methanesulfonyloxymethyl-furan-3-carboxylic acid methyl ester

: 126822-63-7
2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Guidance literature:: With lithium bromide; In tetrahydrofuran; for 0.25h;

Reference yield:

: 126822-71-7
1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

: 126822-63-7
2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) lithium diisopropylamide, 2.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone (DMPU) / 1.) THF, -78 deg C, 45 min, 2.) THF, a) -78 deg C, 30 min, b) RT, 18 h

2: 1.) lithium diisopropylamide / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, -78 deg C, 1 h

3: 1.) ozone, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, RT, 5 h

4: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / -78 °C

5: 90 percent / 10-camphorsulfonic acid / benzene / Heating

6: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, -78 deg C, 40 min, 2.) THF, toluene, -78 deg C, 1 h

7: 97 percent / silver perchlorate / benzene; H₂O

8: 90 percent / NaIO₄, NaHCO₃ / methanol; tetrahydrofuran; H₂O / 5 h

9: 99 percent / sodium borohydride / methanol / -20 °C

10: 100 percent / triethylamine / CH₂Cl₂ / 0.42 h / -10 °C

11: 100 percent / LiBr / tetrahydrofuran / 0.25 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; silver perchlorate; potassium hexamethylsilazane; sodium hydrogencarbonate; ozone; triethylamine; triphenylphosphine; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; benzene;

Reference yield:

: 139897-19-1
(2-bromoethoxy)(tert-butyl)diphenylsilane

: 126822-63-7
2-Bromomethyl-5-((R)-1-{(R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-oxo-2,5-dihydro-furan-2-yl}-2-methyl-allyl)-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 95 percent / sodium iodide / acetone / 36 h / Ambient temperature

2: 1.) lithium diisopropylamide, 2.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone (DMPU) / 1.) THF, -78 deg C, 45 min, 2.) THF, a) -78 deg C, 30 min, b) RT, 18 h

3: 1.) lithium diisopropylamide / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, -78 deg C, 1 h

4: 1.) ozone, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, RT, 5 h

5: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / -78 °C

6: 90 percent / 10-camphorsulfonic acid / benzene / Heating

7: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, -78 deg C, 40 min, 2.) THF, toluene, -78 deg C, 1 h

8: 97 percent / silver perchlorate / benzene; H₂O

9: 90 percent / NaIO₄, NaHCO₃ / methanol; tetrahydrofuran; H₂O / 5 h

10: 99 percent / sodium borohydride / methanol / -20 °C

11: 100 percent / triethylamine / CH₂Cl₂ / 0.42 h / -10 °C

12: 100 percent / LiBr / tetrahydrofuran / 0.25 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; silver perchlorate; potassium hexamethylsilazane; sodium hydrogencarbonate; ozone; triethylamine; triphenylphosphine; sodium iodide; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; benzene;