Technology Process of (R)-N-[(1-benzyl-1H-[1,2,3]triazol-4-yl)-(4-bromophenyl)-methyl]amine
There total 5 articles about (R)-N-[(1-benzyl-1H-[1,2,3]triazol-4-yl)-(4-bromophenyl)-methyl]amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(4-bromophenyl)prop-2-yn-1-amine;
CAL-B;
In
diethyl ether;
at 20 ℃;
Enzymatic reaction;
kinetic resolution of racemate;
benzyl chloride;
With
sodium azide; copper(II) sulfate; sodium L-ascorbate;
In
water; tert-butyl alcohol;
at 125 ℃;
for 0.166667h;
Further stages.;
microwave irradiation;
DOI:10.1016/j.tetasy.2007.06.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 2 h / 20 °C
2.1: sulfuric acid / 20 °C
3.1: HCl / 70 °C
4.1: CAL-B / diethyl ether / 20 °C / Enzymatic reaction; kinetic resolution of racemate
4.2: sodium azide; sodium ascorbate; copper(II) sulfate pentahydrate / H2O; 2-methyl-propan-2-ol / 0.17 h / 125 °C / microwave irradiation
With
hydrogenchloride; sulfuric acid;
CAL-B;
In
tetrahydrofuran; diethyl ether;
2.1: Ritter reaction;
DOI:10.1016/j.tetasy.2007.06.007
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 20 °C
2.1: HCl / 70 °C
3.1: CAL-B / diethyl ether / 20 °C / Enzymatic reaction; kinetic resolution of racemate
3.2: sodium azide; sodium ascorbate; copper(II) sulfate pentahydrate / H2O; 2-methyl-propan-2-ol / 0.17 h / 125 °C / microwave irradiation
With
hydrogenchloride; sulfuric acid;
CAL-B;
In
diethyl ether;
1.1: Ritter reaction;
DOI:10.1016/j.tetasy.2007.06.007
