2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol

Base Information

• Chemical Name: 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol
• CAS No.: 74200-38-7
• Molecular Formula: C₁₉H₃₀O₄
• Molecular Weight: 322.445
• Mol file: 74200-38-7.mol

Synonyms:2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol

Chemical Property of 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol

There total 2 articles about 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone (53123-88-9) → 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol (74200-38-7) + 2-[(R)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-1-methoxy-2-methyl-propyl]-4,6-dimethyl-phenol (74200-33-2,74242-89-0) + 2-[(Z)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2-methyl-propenyl]-4,6-dimethyl-phenol (74200-34-3,74200-35-4) + 2,4-Xylenol (105-67-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1h; Further byproducts given; Heating;

DOI:10.1139/v80-090

Reference yield:

(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone (53123-88-9) → 1-((1R,3S,4S)-3-Hydroxy-4-methoxy-cyclohexyl)-propan-2-one (74200-36-5) + 2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol (74200-38-7) + 2-[(R)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-1-methoxy-2-methyl-propyl]-4,6-dimethyl-phenol (74200-33-2,74242-89-0) + 2,4-Xylenol (105-67-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1h; Further byproducts given; Heating;

DOI:10.1139/v80-090

Reference yield:

2-[(1R,2R)-1-Hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol (74200-38-7) → 2-[(R)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol (74200-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 11 mg / paratoluenesulfonic acid / benzene / 48 h / Ambient temperature

2: 0.198 g / NaOAc / 2 h / 90 °C

3: 60 mg / hydrogen / Adams catalyst / ethanol / 23 h

4: 12 mg / NaOH / ethanol / 0.25 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium acetate; toluene-4-sulfonic acid; platinum(IV) oxide; In ethanol; benzene;

DOI:10.1139/v80-090

upstream raw materials:

(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26⁽⁴²⁾,27⁽⁴³⁾-tetraene-44,45,46,47,48-pentone

Downstream raw materials:

(1R,2R,4R)-2-Methoxy-4-(2,5,7-trimethyl-2,3-dihydro-benzofuran-2-ylmethyl)-cyclohexanol

2-[(Z)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2-methyl-propenyl]-4,6-dimethyl-phenol

2-[(R)-3-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenol

Acetic acid 2-[(R)-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-4,6-dimethyl-phenyl ester