N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Base Information

• Chemical Name: N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide
• CAS No.: 828247-68-3
• Molecular Formula: C₃₅H₅₂N₆O₉Si₂
• Molecular Weight: 757.004
• Mol file: 828247-68-3.mol

Synonyms:N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Chemical Property of N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

There total 1 articles about N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(2-cyanoethoxy)ethane (3386-87-6) → N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (828247-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogen sulfate

2: 75 percent / pyridinium p-toluenesulfonate / dioxane / 55 °C

With sodium hydrogen sulfate; pyridinium p-toluenesulfonate; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2004.10.151

Reference yield: 93.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (828247-68-3) → N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (828247-78-5)

Guidance literature:

N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

4,4'-dimethoxytrityl chloride; In pyridine;

DOI:10.1016/j.tetlet.2004.10.151

Reference yield:

N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (828247-68-3) → Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester (828247-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrabutylammonium fluoride; acetic acid / tetrahydrofuran

1.2: 93 percent / pyridine

2.1: 68 percent / diisopropylethylamine / CH₂Cl₂

With tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2004.10.151

upstream raw materials:

1,2-bis-(2-cyanoethoxy)ethane

Downstream raw materials:

N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester