5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine

Base Information

• Chemical Name: 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine
• CAS No.: 134353-60-9
• Molecular Formula: C₂₅H₂₀N₂O₄S
• Molecular Weight: 444.511
• Mol file: 134353-60-9.mol

Synonyms:5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine

Chemical Property of 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine

There total 5 articles about 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-acetyl-12-hydroxy-11-cyano-5,6-dihydrodibenzazocine (120420-49-7) + p-toluenesulfonyl chloride (98-59-9) → 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine (134353-60-9)

Guidance literature:

With sodium acetate; In 1,4-dioxane; Heating;

DOI:10.1007/BF00633227

Reference yield:

(2-bromomethylphenyl)acetonitrile (73217-11-5) → 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine (134353-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / sodium acetate / propan-2-ol / 1.5 h / Heating

2: 92.5 percent / sodium acetate / dioxane / 0.25 h / Heating

3: 73 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 1 h / Heating

4: 91 percent / sodium acetate / dioxane / Heating

With potassium tert-butylate; sodium acetate; In 1,4-dioxane; isopropyl alcohol; tert-butyl alcohol;

DOI:10.1007/BF00633227

Reference yield:

ethyl N-acetyl-N-<2-(cyanomethyl)benzyl>anthranilate (120420-48-6) → 5-acetyl-12-(p-tosyloxy)-11-cyano-5,6-dihydrodibenzazocine (134353-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 1 h / Heating

2: 91 percent / sodium acetate / dioxane / Heating

With potassium tert-butylate; sodium acetate; In 1,4-dioxane; tert-butyl alcohol;

DOI:10.1007/BF00633227

upstream raw materials:

5-acetyl-12-hydroxy-11-cyano-5,6-dihydrodibenzazocine

p-toluenesulfonyl chloride

(2-bromomethylphenyl)acetonitrile

ethyl ester of N-<(2-cyanomethyl)benzyl>anthranilic acid