tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

Base Information

Chemical Name:tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate
CAS No.:278611-81-7
Molecular Formula:C₂₄H₂₆F₃NO₃
Molecular Weight:433.471
Hs Code.:

Synonyms:tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

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Chemical Property of tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

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Technology Process of tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

There total 1 articles about tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124991-87-3
(4-iodobut-1-yn-1-yl)benzene

: 278611-73-7
tert-butyl 2-[N-(p-methoxyphenyl)imino]-3,3,3-trifluoropropanoate

: 278611-81-7
tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -100 ℃; for 0.0833333h;
DOI:10.1021/jo991917n

Reference yield:

: 278611-81-7
tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

: 2-amino-6-phenyl-2-trifluoromethyl-hex-5-ynoic acid tert-butyl ester

Guidance literature:: With ammonium cerium(IV) nitrate; In acetonitrile; at 20 ℃;
DOI:10.1021/jo991917n

Reference yield:

: 278611-81-7
tert-butyl 6-phenyl-2-[N-(p-methoxyphenyl)amino]-2-trifluoromethyl-5-hexynoate

: 2-amino-6-phenyl-2-trifluoromethyl-5-hexynoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: CAN / acetonitrile / 20 °C

2: 98 percent / aq. HCl / methanol / 12 h / 20 °C

With hydrogenchloride; ammonium cerium(IV) nitrate; In methanol; acetonitrile; 1: oxidative deprotection / 2: Hydrolysis;
DOI:10.1021/jo991917n