methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Base Information

Chemical Name:methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate
CAS No.:340733-45-1
Molecular Formula:C₂₈H₄₂N₄O₈
Molecular Weight:562.663
Hs Code.:

Synonyms:methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

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Chemical Property of methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

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Technology Process of methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

There total 6 articles about methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 340733-44-0
(1-{3-[4-(benzyl-methyl-amino)-phenyl]-2-tert-butoxycarbonylamino-propionyl}-4-tert-butoxycarbonylmethyl-3-oxo-piperazin-2-yl)-acetic acid methyl ester

: 340733-45-1
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;
DOI:10.1248/cpb.49.258

Reference yield:

: 340732-99-2
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-nitrophenyl)propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: 340733-45-1
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10 percent Pd/C / methanol / 1 h

2: 31 percent / NaBH₃CN; AcOH / acetonitrile / 2 h / 20 °C

3: 98 percent / NaBH₃CN; AcOH / acetonitrile / 2 h / 20 °C

4: 100 percent / H₂ / 10 percent Pd/C / methanol / 2 h / 20 °C

With hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1248/cpb.49.258

Reference yield:

: 340733-39-3
methyl 2-[(2S)-1-[(2S)-3-(4-aminophenyl)-2-[(tert-butoxycarbonyl)amino]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: 340733-45-1
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(methylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / NaBH₃CN; AcOH / acetonitrile / 2 h / 20 °C

2: 98 percent / NaBH₃CN; AcOH / acetonitrile / 2 h / 20 °C

3: 100 percent / H₂ / 10 percent Pd/C / methanol / 2 h / 20 °C

With hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1248/cpb.49.258