Technology Process of 4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)thio)N,N-dimethylbenzamide
There total 12 articles about 4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)thio)N,N-dimethylbenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H15ClN2OS;
With
thionyl chloride; triethylamine;
In
acetonitrile;
at 20 - 22 ℃;
for 3h;
(R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
DOI:10.1021/op2003419
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine / methanol; acetonitrile / 0 - 5 °C / Large scale reaction
2.1: sodium sulfide / N,N-dimethyl-formamide / 0.5 h / 60 °C
2.2: 3 h / 60 °C
2.3: 60 °C
3.1: sodium hydroxide / ethanol / 80 °C / Large scale reaction
3.2: Large scale reaction
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; acetonitrile / 1.5 h / 20 °C
5.1: thionyl chloride; triethylamine / acetonitrile / 3 h / 20 - 22 °C
5.2: 16 h / 20 °C
With
sodium sulfide; thionyl chloride; bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/op2003419
