(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

Base Information

Chemical Name:(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide
CAS No.:1379461-16-1
Molecular Formula:C₂₃H₂₇F₃N₂O₆S
Molecular Weight:516.538
Hs Code.:

Synonyms:(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

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Chemical Property of (2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

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Technology Process of (2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

There total 2 articles about (2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 52960-14-2
1-pentylsulfonamide

: 1379461-32-1
(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)acrylic acid

: 1379461-16-1
(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: With dmap; 2-methyl-6-nitrobenzoic anhydride; triethylamine; In acetonitrile; at 20 ℃; for 96h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 1379461-16-1
(2E)-3-(4-(2-methoxyethoxy)-2-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 1.17 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 50 - 120 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 - 60 °C

3.2: 20 °C

4.1: dmap; 2-methyl-6-nitrobenzoic anhydride; triethylamine / acetonitrile / 96 h / 20 °C

With dmap; 2-methyl-6-nitrobenzoic anhydride; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 1.1: Wittig reaction;
DOI:10.1016/j.bmc.2012.03.036