[4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Base Information

• Chemical Name: [4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• CAS No.: 887344-15-2
• Molecular Formula: C₁₁H₁₆F₃NO₄
• Molecular Weight: 283.248
• Mol file: 887344-15-2.mol

Synonyms:[4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property of [4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property:

• PSA: 66.84000
• LogP: 2.05430

Purity/Quality:

99.0%Min ^*data from raw suppliers

4-Trifluoromethyl-pyrrolidine-1,3-dicarboxylicacid1-tert-butylester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

There total 4 articles about [4-(TRIFLUOROMETHYL)PYRROLIDINE]-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

trans-1-tert-butyl 3-ethyl 4-(trifluoromethyl)pyrrolidine-1,3-dicarboxylate → trans-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid (887344-15-2,1808807-76-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

1-tert-butyl (+/-)-(3R,4R)-3-ethyl 4-(trifluoromethyl)pyrrolidine-1,3-dicarboxylate → (3RS,4SR)-4-trifluoromethyl-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (887344-15-2,1808807-76-2)

Guidance literature:

1-tert-butyl (+/-)-(3R,4R)-3-ethyl 4-(trifluoromethyl)pyrrolidine-1,3-dicarboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 25 ℃; for 18h;

With hydrogenchloride; water; In tetrahydrofuran; dichloromethane;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → trans-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid (887344-15-2,1808807-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / ethanol / 8 h / 25 °C / 2585.81 Torr

2: water; lithium hydroxide / methanol; tetrahydrofuran / 20 °C

With palladium on activated charcoal; water; hydrogen; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

di-tert-butyl dicarbonate

trans-ethyl 1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate

Refernces

• 1、 -. "Cyclic amines". Page/Page column 71. . Retrieved 2010/11/24.