[4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol

Base Information

• Chemical Name: [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol
• CAS No.: 152540-05-1
• Molecular Formula: C₉H₇F₃N₂S
• Molecular Weight: 232.229
• Mol file: 152540-05-1.mol

Synonyms:[4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol

Chemical Property of [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol

There total 3 articles about [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-((Acetylthio)methyl)phenyl)-3-(trifluoromethyl)-3H-diazirine (152540-04-0) → [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol (152540-05-1)

Guidance literature:

With sodium methylate; In methanol; for 0.0833333h; Ambient temperature;

DOI:10.1021/jo00078a051

Reference yield:

3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine (92367-11-8) → [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol (152540-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 20 °C

2: sodium methoxide / methanol / 20 °C

With sodium methylate; In methanol; acetonitrile;

DOI:10.1002/chem.200304925

Reference yield:

4-[3-(trifluoromethyl)-3H-diaziren-3-yl]toluene (87736-85-4) → [4-(3-Trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methanethiol (152540-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS; AIBN / CCl₄ / Heating

2: acetonitrile / 20 °C

3: sodium methoxide / methanol / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium methylate; In methanol; tetrachloromethane; acetonitrile;

DOI:10.1002/chem.200304925

upstream raw materials:

3-(4-((Acetylthio)methyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine

4-[3-(trifluoromethyl)-3H-diaziren-3-yl]toluene