tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate
CAS No.:1616059-39-2
Molecular Formula:C₂₃H₂₉N₃O₄
Molecular Weight:411.501
Hs Code.:

Synonyms:tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

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Chemical Property of tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

Chemical Property:

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Technology Process of tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

There total 4 articles about tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 933713-75-8
1-amino-3-(isoindolin-2-yl)propan-2-ol

: 111331-82-9
3-[(tert-butoxycarbonyl)amino]benzoic acid

: 1616059-39-2
tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 21942-58-5
2-(oxiran-2-ylmethyl)isoindoline

: 1616059-39-2
tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethanol / 4 h / 80 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 25 °C

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 496-12-8
isoindoline

: 1616059-39-2
tert-butyl (3-((2-hydroxy-3-(isoindolin-2-yl)propyl)carbamoyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 16 h / 25 °C

2: ammonia / ethanol / 4 h / 80 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 25 °C

With ammonia; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; acetonitrile;