4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride

Base Information

• Chemical Name: 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride
• CAS No.: 947689-79-4
• Molecular Formula: C₁₃H₉ClN₄O₃S
• Molecular Weight: 336.758

Synonyms:4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride

Chemical Property of 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride

Chemical Property:

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Technology Process of 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride

There total 1 articles about 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-{3-[4-(Benzylthio)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-amine (947723-76-4) → 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride (947689-79-4)

Guidance literature:

With water; chlorine; acetic acid; at 5 - 10 ℃; for 0.25h;

Reference yield: 40.0%

N-(3-Amino-5-fluorophenyl)-1-cyanocyclopropanecarboxamide (947689-80-7) + 4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonyl chloride (947689-79-4) → N-{3-[({4-[5-(6-Aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)amino]-5-fluorophenyl}-1-cyanocyclopropanecarboxamide (947689-90-9)

Guidance literature:

With pyridine; at 20 ℃; for 18h;

upstream raw materials:

6-{3-[4-(Benzylthio)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-amine

Downstream raw materials:

N-{3-[({4-[5-(6-Aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)amino]-5-fluorophenyl}-1-cyanocyclopropanecarboxamide

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