1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

Base Information

Chemical Name:1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione
CAS No.:134052-43-0
Molecular Formula:C₁₈H₂₂N₂O₂
Molecular Weight:298.385
Hs Code.:

Synonyms:1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

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Chemical Property of 1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

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Technology Process of 1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

There total 4 articles about 1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

: 134052-48-5
1R,5S-(+)-3-(cyclohexylmethyl)-1-(4-nitrophenyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

: 134052-43-0
1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00108a013

Reference yield:

: 134052-45-2
1R,2S-(+)-1-phenyl-1,2-cyclopropanedicarboxylic acid

: 134052-43-0
1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) xylene, reflux, 5 h, 2.) xylene, reflux, 15 h

2: 45 percent / concd. sulfuric acid, nitric acid / 2 h / 10 °C

3: 77.3 percent / H₂ / 5percent Pd/C / ethyl acetate

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00108a013

Reference yield:

: 134052-46-3
1R,5S-(+)-3-(cyclohexylmethyl)-1-phenyl-3-azabicyclo<3.1.0>hexane-2,4-dione

: 134052-43-0
1R,5S-(+)-1-(4-aminophenyl)-3-(cyclohexylmethyl)-3-azabicyclo<3.1.0>hexane-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / concd. sulfuric acid, nitric acid / 2 h / 10 °C

2: 77.3 percent / H₂ / 5percent Pd/C / ethyl acetate

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00108a013