3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Base Information

• Chemical Name: 3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
• CAS No.: 886886-04-0
• Molecular Formula: C6H10 N4
• Molecular Weight: 138.17
• Hs Code.: 2933990090
• Mol file: 886886-04-0.mol

Synonyms:3-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;3-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-¨￠a]pyrazine

Chemical Property of 3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.723
• Boiling Point: 340.651°C at 760 mmHg
• Flash Point: 159.82°C
• PSA: 42.74000
• Density: 1.44g/cm³
• LogP: 0.01850
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

5,6,7,8-Tetrahydro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6,7,8-Tetrahydro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine is used as a reagent to synthesize pyrrolo[2,3-b]pyridine compounds which have the potential to act as antiviral agents against specific viruses of the retrovirus family (such as the human immunodeficiency virus [HIV]).

Technology Process of 3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

There total 1 articles about 3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-s-triazolo<4,3-a>pyrazin (33590-17-9) → 3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (886886-04-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 72h;

Reference yield: 53.0%

3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (886886-04-0) + 4-Carboxybenzaldehyde (619-66-9) → 4-(3-methyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)benzaldehyde

Guidance literature:

4-Carboxybenzaldehyde; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01709

Reference yield:

3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (886886-04-0) → N-(4-methoxybenzyl)-5-(3-(6-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine (1401348-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane / 4 h / 140 °C / Microwave irradiation

2: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 100 - 120 °C / Microwave irradiation

With water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;

upstream raw materials:

3-Methyl-s-triazolo<4,3-a>pyrazin

Downstream raw materials:

N-(4-methoxybenzyl)-5-(3-(6-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 886886-04-0 3-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send