2-Methoxyquinoline-3-boronic acid

Base Information

• Chemical Name: 2-Methoxyquinoline-3-boronic acid
• CAS No.: 886853-93-6
• Molecular Formula: C10H10BNO3
• Molecular Weight: 203.005
• Hs Code.: 2933499090
• Mol file: 886853-93-6.mol

Synonyms:Boronicacid, (2-methoxy-3-quinolinyl)- (9CI);

Chemical Property of 2-Methoxyquinoline-3-boronic acid

Chemical Property:

• Vapor Pressure: 1.33E-07mmHg at 25°C
• Melting Point: 254 °C
• Refractive Index: 1.62
• Boiling Point: 414.2 °C at 760 mmHg
• PKA: 7.10±0.30(Predicted)
• Flash Point: 204.3 °C
• PSA: 62.58000
• Density: 1.29 g/cm³
• LogP: -0.07680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxyquinoline-3-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxyquinoline-3-boronic acid

There total 7 articles about 2-Methoxyquinoline-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxy-quinoline (6931-16-4) + Triisopropyl borate (5419-55-6) → 2-methoxy-3-quinolin-3-ylboronic acid (886853-93-6)

Guidance literature:

2-methoxy-quinoline; Triisopropyl borate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield: 95.0%

2-methoxy-quinoline (6931-16-4) → 2-methoxy-3-quinolin-3-ylboronic acid (886853-93-6)

Guidance literature:

2-methoxy-quinoline; With Triisopropyl borate; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jo062228w

Reference yield:

C12H14BNO3 → 2-methoxy-3-quinolin-3-ylboronic acid (886853-93-6)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃;

DOI:10.1039/c6ob01893a

upstream raw materials:

2-methoxy-quinoline

2-Chloroquinoline

Triisopropyl borate

3-bromoquinolin-2-one

Refernces

• 1、 Priebbenow, Daniel L.,Barbaro, Lisa,Baell, Jonathan B.. "New synthetic approaches towards analogues of bedaquiline". . p. 9622 - 9628. Retrieved 2016/10/25.
• 2、 Fang, Yuan-Qing,Karisch, Robert,Lautens, Mark. "Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/suzuki coupling as the key step". . p. 1341 - 1346. Retrieved 2007/10/03.